Clinical trial report: the electrocardiographic response to ajmaline provocation in healthy subjects

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): British Heart Foundation The Robert Lancaster Memorial Fund sponsored by McColl’s Research Group Background electrocardiographic (ECG) response to diagnostic ajmaline provocation (AP) testing has been studied extensively in clinical cohorts. However, the healthy ECG not described. We undertook a trial examining changes AP cohort systematically recruited asymptomatic Caucasian subjects with no family history sudden death and normal baseline echocardiogram. Methods Applicants responded national recruitment advertisement completed an online medical questionnaire. Those fulfilling inclusion criteria were invited undergo further evaluation eligible undergoing challenge (1mg/kg, max. 100mg over 5 minutes). A continuous was recorded standard high right precordial lead (HRPL) position. Automated analysis conventional novel measurements made at peak drug effect, which defined as point maximum QRS duration (excluding leads). Results One hundred underwent AP. mean age 26.84 years (SD ± 8.01 years) 52% male. induced type 1 Brugada pattern (DI-T1BP) observed 3/100 (3%) cohort. performed paired comparison measures versus effect (Table 1). had similar on global PR interval, both increasing 28%, ∆ 25.66ms 43.36ms respectively. Changes S wave parameters II pronounced, 97% increase 101% negative amplitude. ST-J elevation anterior, inferior, lateral regions comparable, 57%, 51% 57% amplitude greater cardiac conduction females compared males 2). In contrast, STJ combined segmented QRST segment area males. Conclusion elicits pronounced conduction, more so males, whilst male subjects. DI-T1BP is part